Eric Topol ✓

Peripheral arterial disease is the focus of a new @TheLancet series with 3 articles, open-access https://t.co/zM4PzS5lth https://t.co/9cwUoViWeF https://t.co/IFBrNuQOR9

17.7K views · 137 likes · 34 reposts · 2 replies Open on X →

We're missing out on the value of genomics in medical practice. The cost (not charge) to do a polygenic risk score for all these diseases (Figure) and more is only $20 and they are informative for high-risk (top 5%) across ancestries A new review @NEJM https://t.co/m2NanqQvhM ht

19.4K views · 189 likes · 39 reposts · 11 replies Open on X →

The cardiovascular benefit from Ozempic in the large randomized trial was substantially not related to weight loss https://t.co/20rQ7odyWx https://t.co/xcRaBvBiLs

31.7K views · 416 likes · 66 reposts · 13 replies Open on X →

Fat cells are a key component of our immune system but that's not generally acknowledged. An insightful review of their contributions @Cell_Metabolism https://t.co/p95SSAU8YV https://t.co/bA82ysQrey

22.7K views · 282 likes · 84 reposts · 4 replies Open on X →

@EricTopol Listening in on the #OSSUResearchDay2026 "Your postal code matters more to your health than your genetic code. Genetics are only responsible for 15% for health effects." 54 views · 0 likes · 1 reposts · 0 replies Open on X →

@EricTopol Population level vs or alongside individual level ? 65 views · 1 likes · 0 reposts · 0 replies Open on X →

@EricTopol Fascinating. But in a sign of the time, also already out of date, given the relatively limited discussion of agents? We're going to need a quicker publishing model/knowledge ecology? 245 views · 1 likes · 0 reposts · 0 replies Open on X →

The GRAIL NHS Galleri randomized trial with over 142,000 participants was published today @NEJM "In this trial, we did not observe a lower incidence rate of stage III or IV cancers [the primary endpoint] across 12 prespecified cancers after three screening rounds with multicancer

25.7K views · 145 likes · 33 reposts · 15 replies Open on X →

The link between some ultraprocessed foods and chronic diseases among 8.8 million people, 51 prospective cohorts, with a dose response effect https://t.co/yhGEl5BpBK https://t.co/2Za9zmRaTB

15.6K views · 146 likes · 38 reposts · 3 replies Open on X →

Eric Topol ✓@EricTopol22 Sep

On the millions of people (by now) taking GLP-1 drugs off-label https://t.co/LP6z0Wls27 https://t.co/qTQTRlBmNK

20.2K views · 52 likes · 12 reposts · 8 replies Open on X →

Eric Topol ✓@EricTopol22 Sep

8 words that are saying a lot "AI now functions as a determinant of health" https://t.co/xxEgq3Y3Sa 26.9K views · 129 likes · 40 reposts · 7 replies Open on X →

Timely, @Thelancet on GRAIL today! "To date, there is no evidence that any multicancer detection testing prevents cancer, consistently detects it at an earlier stage, or reduces cancer-associated mortality. Meanwhile, false-positive rates have been predictably high. The costs 33.6K views · 192 likes · 45 reposts · 15 replies Open on X →

In its pivotal clinical trial, the GRAIL test to detect early cancer failed its primary endpoint. It detected only 3 early cases per 1,000 people assessed. There were more false negative results (N=196) than true positives (N=133). Reviewed here https://t.co/SuSTyk23Tr But you ht

77.6K views · 309 likes · 85 reposts · 29 replies Open on X →

The potential to predict breast and prostate cancer up to 8 years before it is diagnosed from blood cell-free DNA methylation patterns https://t.co/1fv5Pi4TR6 36.6K views · 504 likes · 129 reposts · 6 replies Open on X →

In a prospective study of Type 1 diabetes getting diagnosed in children, strong evidence for the gut microbiome pattern of development ("early plateaued") and heightened risk https://t.co/RjPCcbhc91 https://t.co/aCuszyQSu4

20.1K views · 70 likes · 14 reposts · 5 replies Open on X →

“Here we argue that AI now functions as a determinant of health” https://t.co/xxEgq3Y3Sa https://t.co/8eJ0awmUwz

15.8K views · 120 likes · 30 reposts · 5 replies Open on X →

The irony of it all. Yesterday, @NEJM posted a new essay suggesting that the US government attacks on biomedical science will now subside. https://t.co/ihIN6dNK57 On the same day, it was announced the President wants control of NIH funding. https://t.co/nsV3NA8CWr https://t.co/k

25.3K views · 210 likes · 86 reposts · 10 replies Open on X →

The informativeness of a chest X-ray decoded by AI In this multimodal AI model called Oncoformer of 3.67 million individuals of EHR plus chest X-ray, cancer was predicted at least 1 year before diagnosis: AUROC all cancers 0.869, cervical cancer 0.905, colon cancer 0.896 https://

24.8K views · 196 likes · 52 reposts · 15 replies Open on X →

Your wearable sensor gives you HRV and Readiness/Recovery/Fitness Scores. What are they? Are they validated? Should you work to get these metrics higher? https://t.co/Xgp8o2yHJB @ouraring @Apple @Garmin @WHOOP @eightsleep @googlehealth https://t.co/MIwV4Bjhpe

37.6K views · 166 likes · 35 reposts · 15 replies Open on X →

Eric Topol ✓@EricTopol19 Sep

Over 100 million Americans use wearable sensors, including smartwatches, rings, and wrist bands. They provide data for HRV and Readiness scores. What is the story with these metrics? https://t.co/AgDx4ezBBF

33.8K views · 186 likes · 36 reposts · 11 replies Open on X →

How regular exercise enhances our immune response. A multiomic blood assessment (single-cell RNA, epigenetics, metabolites, lipids, and cells) with distinct signature for exercise vs sedentary lifestyle @ScienceAdvances https://t.co/mcgPrLSyJ5 https://t.co/XKlwYiPFbw

31.4K views · 342 likes · 77 reposts · 15 replies Open on X →

Thanks to opportunistic AI imaging, a new window into the kidney: via the heart echocardiogram! @David_Ouyang https://t.co/kl0a7uhNh7 https://t.co/a9FnFdz1ps

26.7K views · 90 likes · 14 reposts · 8 replies Open on X →

The role of the brain's oligodendrocytes for health and disease is well beyond common perception of its role in myelination, as this new @CellCellPress illuminates https://t.co/7pHDVm4M1r https://t.co/CQCc2Dp0Q3

21.6K views · 123 likes · 17 reposts · 1 replies Open on X →

Chronic inflammation's toll on the heart muscle and function, from factors such as stress, one of the strongest determinants, as shown in ~500,000 @uk_biobank participants https://t.co/GOYBSp1spJ https://t.co/cg8s8gnlBE

17.1K views · 161 likes · 42 reposts · 6 replies Open on X →

Real world sleep patterns and disease risk from >95,000 @uk_biobank participants @PLOSMedicine 6-8 hours of sleep duration is good and "can effectively reduce the risk of multiple diseases" (but that implies cause and effect, not established ) More REM linked to lower risk of 83

11.7K views · 122 likes · 30 reposts · 6 replies Open on X →

First release @ScienceMagazine "Virtual Biotech," whereby >37,000 AI agents were put to work to find targets and forecast success in clinical trials, both for efficacy and avoidance side-effects. And that was one the first of a series of accomplishments @james_y_zou https://t.c

19.7K views · 166 likes · 42 reposts · 5 replies Open on X →

Discovery of a rare gene EGFR variant that predisposes to lung cancer, a 25-fold risk among carriers, a risk that exceeds smoking, high-risk seen in non-smokers, on the cover @ScienceMagazine, with trace of origin to a Southern Appalachia founder event https://t.co/TZ0vi4GFuf htt

20.8K views · 231 likes · 66 reposts · 5 replies Open on X →