KIReports

@KIReports · New York, USA · joined 27 Sep 2017

Kidney International Reports | Official journal of @ISNkidneycare | Tweets by KI Reports Social Media team | 👀https://t.co/I6LNofZoQ2

14 278Followers

350Following

8 567Posts total

7.3KViews on collected posts

โพสต์ล่าสุด

KIReports@KIReports6 Sep

@KIReports @AgavriloaeiB @assad_sm @DrAkshayaJ @ISNkidneycare @ISNeducation @sophia_kidney @MChanMD @brian_rifkin @CristinaDeReins I’m curious whether the vascular effect tracks citrate exposure itself or the transient drop in ionized Ca—does the study separate those mechanisms? 16 views · 0 likes · 0 reposts · 0 replies Open on X →

KIReports@KIReports6 Sep

18/ Thank you for reading! This paper is a reminder that dialysis prescriptions can have biological effects we may not predict from short-term biochemical markers. Read the full KI Reports paper and keep questioning the mechanism. 🧵@DrAkshayaJ https://t.co/0Kf2DgxL4i https: 143 views · 2 likes · 0 reposts · 0 replies Open on X →

KIReports@KIReports6 Sep

16/ So, should we stop citrate dialysate? No. This is a small, single-center study with a selected population and surrogate endpoint. But the signal is striking enough to justify larger studies with robust exposure assignment, imaging and clinical outcomes. https://t.co/3IOe0mXT 251 views · 4 likes · 2 reposts · 1 replies Open on X →

KIReports@KIReports6 Sep

15/ The study also challenges an interesting disconnect: citrate dialysate can improve short-term serum calcification propensity, yet this study found faster progression of vascular calcification. A better biomarker does not automatically mean a better tissue-level outcome. 23 views · 3 likes · 0 reposts · 1 replies Open on X →

KIReports@KIReports6 Sep

14/ Limitations 5 patients may have had dialysate errors, based on unexpectedly ⬆️ citrate levels during the acetate arm BAC is a surrogate This study did not measure coronary/aortic Ca, calciphylaxis, CV events or mortality. We cannot conclude that citrate dialysate⬆️ CV risk 22 views · 2 likes · 0 reposts · 1 replies Open on X →

KIReports@KIReports6 Sep

13/ Why is this surprising? Citrate is a calcium chelator and can inhibit calcium phosphate crystallization. But citrate is also abundant in bone and participates in biomineralization. So its biological effect may depend on context, concentration and tissue environment. 98 views · 4 likes · 1 reposts · 1 replies Open on X →

KIReports@KIReports6 Sep

12/ Then came the intriguing tissue finding. Citrate was detected in calcified human arterial segments. Citrate content correlated strongly with the amount of calcification (r=0.91). Estimated citrate content was ~0.8% of calcified tissue. 101 views · 3 likes · 2 reposts · 1 replies Open on X →

KIReports@KIReports6 Sep

11/ The striking biochemical difference was citrate itself. Pre-HD citrate was similar, but post-HD citrate rose to 383 vs 187 μM with citrate vs acetate. That >3-fold rise makes citrate a plausible contributor, but does not prove causality. https://t.co/LqhRvWfsmO 99 views · 3 likes · 1 reposts · 1 replies Open on X →

KIReports@KIReports6 Sep

10/ Could Ca, phosphate or dialysis adequacy explain it? Not really. Pre-HD Ca and phosphate, dialysis time, Kt/V and dialysate Ca were similar. Citrate did lower post-HD ionized Ca and Mg, while HCO3 and PTH were slightly higher. https://t.co/wsGXACaW4O 103 views · 4 likes · 1 reposts · 1 replies Open on X →

KIReports@KIReports6 Sep

9/ The finding was also seen as % change from baseline: 40%/yr with citrate vs 21%/yr with acetate. The effect was significant whether patients started with citrate or acetate, supporting consistency within the crossover design. https://t.co/1CN138vDKC 92 views · 3 likes · 1 reposts · 1 replies Open on X →

KIReports@KIReports6 Sep

8/ The headline result: BAC progressed much faster with citrate. Median progression was 47 mm/yr with citrate vs 9 mm/yr with acetate. (P=0.0005) 22 of 28 patients had greater progression during citrate exposure. https://t.co/QYP9VmfrMI 30 views · 2 likes · 0 reposts · 1 replies Open on X →

KIReports@KIReports6 Sep

7/ The cohort was small and highly selected: all 28 were women and African American. Of 54 who started, only 29 completed the protocol, and 28 had usable BAC progression data. The attrition matters when interpreting the magnitude of the finding. https://t.co/m0I1ZKNAuS 25 views · 4 likes · 0 reposts · 1 replies Open on X →

KIReports@KIReports6 Sep

6/ Study design : This was a crossover study. 28 women on chronic HD with pre-existing BAC received citrate or acetate dialysate for ~1 year each, with mammograms at 6-month intervals. Each patient therefore served as her own control. https://t.co/M6fbu3CNjf 26 views · 2 likes · 0 reposts · 1 replies Open on X →

KIReports@KIReports6 Sep

5/ The study used breast arterial calcification (BAC) as a marker of medial vascular calcification, answer “A”. BAC is visible on routine mammography and reflects medial rather than atherosclerotic intimal calcification. https://t.co/rwJRUGFYWb 100 views · 4 likes · 2 reposts · 1 replies Open on X →

KIReports@KIReports6 Sep

4/ Poll : What is breast arterial calcification (BAC) most reflective of? 34 views · 2 likes · 1 reposts · 1 replies Open on X →

KIReports@KIReports6 Sep

3/ Our #Xtorial is by Akshaya J @DrAkshayaJ, adult nephrologist from @CMCNephrology - No COI #MedTwitter @ISNkidneycare Check out #KIReportsCommunity educational #blogposts at https://t.co/AgY6mXQU75. FOLLOW US at @KIReports https://t.co/jdjZqH5pw1 210 views · 6 likes · 2 reposts · 1 replies Open on X →

KIReports@KIReports6 Sep

2/ A new KI Reports study asks a provocative question : does citrate-containing dialysate affect vascular calcification in HD? https://t.co/0Kf2DgxL4i The answer was unexpected. Let’s look at the study, the signal, and what we should make of it. https://t.co/9lu2VmH0BO 206 views · 3 likes · 0 reposts · 1 replies Open on X →

KIReports@KIReports6 Sep

1/ Hey #NephX! 👋 We’re back with a fresh #Xtorial from KIReports Citrate dialysate is often viewed as a friend in dialysis : it chelates Ca, and inhibits Ca/Phos crystallization, But what if the effect on the vessel wall is not so simple? https://t.co/0Kf2DgxL4i https://t.co/R 1.6K views · 22 likes · 13 reposts · 2 replies Open on X →

KIReports@KIReports4 Sep

19/ We hope this #tweetorial improved your understanding of donor & recipient diabetes in KT. Please share! Thanks to @ManoleaA for authoring & @sophia_kidney for great feedback! @ISNkidneycare @KIReports 🔗https://t.co/V4jQZ0foqK 196 views · 2 likes · 1 reposts · 0 replies Open on X →

KIReports@KIReports4 Sep

18/ Based on this evidence, does this change your perspective on using kidneys from donors with diabetes for transplantation? Please comment! 142 views · 1 likes · 0 reposts · 1 replies Open on X →

KIReports@KIReports4 Sep

16/ Summary ⚡ Donor diabetes status alone did not worsen graft or patient survival ⚡ D+/R+ had the poorest graft and patient survival ⚡ eGFR was only slightly lower, with no difference in rejection 27 views · 0 likes · 0 reposts · 1 replies Open on X →

KIReports@KIReports4 Sep

17/ Limitations 👎 Observational registry study, with potential residual confounding 👎 Relatively small D+/R+ group (n=189) 👎 No data on diabetes severity, duration, treatment or HbA1c 👎 Lack of kidney biopsy data to assess diabetic kidney changes 25 views · 1 likes · 0 reposts · 1 replies Open on X →

KIReports@KIReports4 Sep

15/ Results: 2° Outcomes ⚕️ No significant difference in rejection between groups ⚕️ Diabetic donor kidneys were associated with only a minor reduction in eGFR 📉 The difference was small during the first 5 years post-transplant 📈 D−/R− recipients had the best eGFR over time https 28 views · 1 likes · 0 reposts · 1 replies Open on X →

KIReports@KIReports4 Sep

14b/ Results: Graft Survival 👤 Diabetic recipients had reduced overall graft survival 📊 D+/R+: aHR 1.52 (95% CI 1.16–1.98) 📊 D−/R+: aHR 1.19 (95% CI 1.03–1.36) https://t.co/7GsxJebN3i 20 views · 1 likes · 0 reposts · 1 replies Open on X →

KIReports@KIReports4 Sep

14a/ Results: Patient Survival 🫘 Death-censored graft survival was similar for most donor–recipient combinations 🫘 D+/R+ had significantly worse patient survival 📊 aHR 1.70 (95% CI 1.15–2.51) 🫘 D−/R+ had reduced patient survival 📊 aHR 1.38 (95% CI 1.18–1.61) https://t.co/rtkYEGur 23 views · 1 likes · 0 reposts · 1 replies Open on X →

KIReports@KIReports4 Sep

13/ Results: Cohort & Follow-up 💊 11,343 kidney transplant recipients included 💊 Median follow-up: 6.16 years 💊 3,427 graft losses and 2,532 deaths 💊 Only 124 patients were lost to follow-up 24 views · 1 likes · 0 reposts · 1 replies Open on X →

KIReports@KIReports4 Sep

12/ Results: Clinical Characteristics The D+/R+ group was: 🔬 Older 🔬 More often male 🔬 Higher BMI 🔬 More cardiovascular & peripheral vascular disease 🔬 Mostly T2DM For diabetic donors: 🫘 Older and higher BMI 🫘 More hypertension 🫘Similar terminal creatinine https://t.co/GlDCuRZh9 26 views · 1 likes · 0 reposts · 1 replies Open on X →

KIReports@KIReports4 Sep

11/ Outcomes 🎯Primary: Death-censored graft survival ➕ Secondary: Patient survival, overall graft survival, acute rejection at 12 months, and post-transplant eGFR over time 29 views · 1 likes · 0 reposts · 1 replies Open on X →

KIReports@KIReports4 Sep

10b/ Methods 🎗️ Inclusion: First-time adult (≥18 years) recipients of a deceased-donor kidney transplant ❌ Exclusion: Living-donor, repeat, and multi-organ transplants; missing donor or recipient diabetes status 30 views · 1 likes · 0 reposts · 1 replies Open on X →

KIReports@KIReports4 Sep

10a/ Methods 💽 Data: Australia and New Zealand Dialysis and Transplant Registry (ANZDATA) 🕐2003–2022 🫘 11,343 first-time adult recipients of deceased-donor kidney transplants 🔄 Compared 4 donor–recipient diabetes combinations: D−/R−, D−/R+, D+/R−, D+/R+ 34 views · 2 likes · 0 reposts · 1 replies Open on X →

เทียบกับบัญชีขนาดเดียวกัน

41 โพสต์จาก 90 วันที่ผ่านมา เทียบกับช่วง 10K–100K ผู้ติดตาม เข้าถึงคนน้อยกว่าบัญชีรุ่นเดียวกัน แต่ดึงการมีส่วนร่วมได้แรงกว่ามาก.

ยอดดูมัธยฐาน61บัญชีนี้949ค่ามัธยฐานของ 10K–100K

การเข้าถึง, %0.43%บัญชีนี้3.31%ค่ามัธยฐานของ 10K–100K

การมีส่วนร่วม, %6.12%บัญชีนี้1.88%ค่ามัธยฐานของ 10K–100K

ตัวชี้วัด	บัญชีนี้	ค่ามัธยฐานของ 10K–100K	อัตราส่วน
ยอดดูมัธยฐานต่อโพสต์	61	949	0.06×
การเข้าถึง (ยอดดู ÷ ผู้ติดตาม)	0.43%	3.31%	0.13×
อัตราการมีส่วนร่วม	6.12%	1.88%	3.25×

บัญชีอื่นในช่วงนี้ → เปรียบเทียบกับบัญชีอื่น → ค่าอ้างอิงเหล่านี้คำนวณอย่างไร →

Growth & engagement

How the posts we collected actually performed: views and reaction rate post by post, what the audience did with them, and where the follower count goes.

Views per post

1006 Sep

103

101

251

143

Last 14 collected posts, oldest on the left. The scale is logarithmic: one post can outrun the rest a hundred times over.

Engagement rate per post

7.00%6 Sep

11.54%

20.00%

10.00%

5.43%

5.83%

5.05%

5.94%

6.12%

13.64%

17.39%

2.79%

1.40%

0.00%

Reactions — likes, reposts, replies and quotes — divided by views. Median for 10K–100K accounts is 1.88%.

What the audience does

Likes58.1%86 in total

Reposts18.2%27 in total

Replies18.9%28 in total

Quotes2.7%4 in total

Bookmarks2.0%3 in total

Share of every reaction we collected for this account. Replies mean argument, reposts mean endorsement, bookmarks mean the post was worth keeping.

The follower curve appears once this account has two daily snapshots — we take one a day, and this one is on its first.

โพสต์ล่าสุด

เทียบกับบัญชีขนาดเดียวกัน

Growth & engagement

Views per post

Engagement rate per post

What the audience does

บัญชีที่คล้ายกัน