Sam Tsimikas, MD ✓

@Lpa_Doc · San Diego, CA · joined 25 Oct 2016

Educational forum on Lp(a) and related areas. Professor UC San Diego.

15 949Followers

103Following

4 752Posts total

23.3KViews on collected posts

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Sam Tsimikas, MD ✓@Lpa_Doc10 Sep

You did not measure OxPL in your Lp(a) prep, thus cant claim your findings are due to OxPL. Oxidizing with glucose oxidase and MPO likely creates a large number of species that could explain your results. t would be good to tease those out in future studies. 4.4K views · 23 likes · 2 reposts · 2 replies Open on X →

Sam Tsimikas, MD ✓@Lpa_Doc9 Sep

Statins raise Lp(a), and because it carries OxPL, the OxPL-apoB rises (note the OxPL-apoB is not a measure of "total OxPL"). Statins lower the # of LDL particles substantially, more ta increase in Lp(a)/OxPL, thus the net benefit is present. In SPARCL it was baseline OxPL, not 12K views · 74 likes · 11 reposts · 8 replies Open on X →

Sam Tsimikas, MD ✓@Lpa_Doc9 Sep

Does native Lp(a) provide an evolutionary benefit and possess important physiological functions? Substantial evidence suggests that OxPL carried by Lp(a) is a major driver of Lp(a) pathogenicity---and OxPL burden is a stronger predictor of cardiovascular risk than Lp(a) https://

4.6K views · 0 likes · 0 reposts · 0 replies Open on X →

Sam Tsimikas, MD ✓@Lpa_Doc9 Sep

Yes, this can't be studied in patients, but in experimental models, it suggests OxPL exit tissue before there is physical regression when switching from high fat to low fat diet. See our 2007 paper. https://t.co/gsAAQCASMy https://t.co/YXCTHJTcex

1.2K views · 4 likes · 2 reposts · 3 replies Open on X →

Sam Tsimikas, MD ✓@Lpa_Doc9 Sep

@Lpa_Doc @JACCJournals @OxPL_apoB But you would expect oxPL-apoB to be drastically reduced with pelacarsen as well, right? But the real question is what happens in the tissues! 1.1K views · 0 likes · 0 reposts · 1 replies Open on X →

Sam Tsimikas, MD ✓@Lpa_Doc26 Feb 2022

For those interested in the Saturday Morning Lp(a) Class, the course is now linked to my bio and is open access. Big thanks to @TheBhupiThakur for organizing the twittorials. It is ~500 tweets in 24 classes. Syllabus enclosed. I wish to all the joy of learning. https://t.co/iOFHB

0 views · 249 likes · 33 reposts · 21 replies Open on X →

Sam Tsimikas, MD ✓@Lpa_Doc25 Feb 2022

All Sat morning classes by @Lpa_Doc is now linked to this updated thread. Enjoy 0 views · 47 likes · 13 reposts · 1 replies Open on X →

เทียบกับบัญชีขนาดเดียวกัน

5 โพสต์จาก 90 วันที่ผ่านมา เทียบกับช่วง 10K–100K ผู้ติดตาม แสดงในวงกว้าง แต่มีผู้ชมตอบสนองน้อย.

ยอดดูมัธยฐาน4 392บัญชีนี้987ค่ามัธยฐานของ 10K–100K

การเข้าถึง, %27.54%บัญชีนี้3.79%ค่ามัธยฐานของ 10K–100K

การมีส่วนร่วม, %0.61%บัญชีนี้1.52%ค่ามัธยฐานของ 10K–100K

ตัวชี้วัด	บัญชีนี้	ค่ามัธยฐานของ 10K–100K	อัตราส่วน
ยอดดูมัธยฐานต่อโพสต์	4 392	987	4.45×
การเข้าถึง (ยอดดู ÷ ผู้ติดตาม)	27.54%	3.79%	7.27×
อัตราการมีส่วนร่วม	0.61%	1.52%	0.40×

บัญชีอื่นในช่วงนี้ → เปรียบเทียบกับบัญชีอื่น → ค่าอ้างอิงเหล่านี้คำนวณอย่างไร →

Growth & engagement

How the posts we collected actually performed: views and reaction rate post by post, what the audience did with them, and where the follower count goes.

Views per post

1.1K9 Sep

1.2K

4.6K

12K

4.4K10 Sep

Last 5 collected posts, oldest on the left. The scale is logarithmic: one post can outrun the rest a hundred times over.

Engagement rate per post

0.09%9 Sep

0.74%

0.00%

0.78%

0.61%10 Sep

Reactions — likes, reposts, replies and quotes — divided by views. Median for 10K–100K accounts is 1.52%.

What the audience does

Likes48.1%101 in total

Reposts7.1%15 in total

Replies6.7%14 in total

Bookmarks38.1%80 in total

Share of every reaction we collected for this account. Replies mean argument, reposts mean endorsement, bookmarks mean the post was worth keeping.

The follower curve appears once this account has two daily snapshots — we take one a day, and this one is on its first.

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เทียบกับบัญชีขนาดเดียวกัน

Growth & engagement

Views per post

Engagement rate per post

What the audience does

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