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The Journal of Immunology

@J_Immunol · joined 16 Oct 2015

The Journal of Immunology is an official journal of The American Association of Immunologists, Inc., @ImmunologyAAI.

24 901Followers
1 357Following
5 067Posts total
6.7KViews on collected posts

Ultimi post

@J_Immunol Wildling mice showed faster memory T-cell turnover, but their naïve T cells still relied on the thymus. In adults, human naïve T cells are maintained mostly by cell division. A natural microbiome does not erase the species gap. https://t.co/hokeU2xguH 11 views · 0 likes · 0 reposts · 0 replies Open on X →
Data show that the processes underlying T cell homeostasis are affected by age, species, and microbial exposure and even laboratory mice born to wild mice do not capture all age-related changes in T cell maintenance observed in humans. Read more: https://t.co/EYe9ZsSDs4. https://
Percentage and number of naive and memory T cells over age in standard lab mice and wildlings.
1.3K views · 26 likes · 0 reposts · 1 replies Open on X →
New data show that skullcapflavone II (SkII) alleviates osteoarthritis progression by inhibiting ferroptosis. The potent effects of SkII are largely attributable to its antiferroptotic activity, highlighting its significant clinical potential. Read more: https://t.co/IUBfD9kXhY.
SkII attenuated ferroptosis in vivo. (A–C) The concentrations of MDA and Fe2+, and the activity of SOD in cartilage tissues, were measured. (D–F) The mRNA level of indicated genes in cartilage tissues was analyzed by qRT-PCR. (G) The protein level of ETV4, SLC7A11, GPX4, and cleaved caspase-3 in cartilage tissues was analyzed by Western blotting. For all the statistical data, the data are presented as the mean ± SD, and the statistical significance of the differences among groups was assessed using 1-way analysis of variance. Blank versus model, ## P \x3C 0.01; model versus SkII, *P \x3C 0.05, **P \x3C 0.01 (n = 6).
825 views · 7 likes · 0 reposts · 0 replies Open on X →
New data provides insights into the signaling pathways that induce neutrophil extracellular traps in response to SARS-CoV-2, highlighting new targets for studies and therapies for COVID-19. Find the full paper in The JI: https://t.co/uyldMYCrjV. https://t.co/BkPRqIX83a
Proteins involved in the generation of ROS are increased in neutrophils from patients with COVID-19. (A) BALs from pneumonia patients were analyzed, and evaluated cohorts were divided into patients with pneumonia without COVID-19 (13 patients) and COVID-19 (22 patients). (B) Single-cell RNA sequencing demonstrates the cell types present during COVID-19 infection and pneumonia without COVID-19. (C) Analysis of genes that encode NOX2-forming proteins in neutrophils from BAL of patients with COVID-19. (D) Assessment of labeling with the MitoSOX staining in airway aspirate from a patient with COVID-19. Images are representative of 5 independent experiments. tSNE, t-distributed stochastic neighbor embedding.
1.2K views · 14 likes · 4 reposts · 1 replies Open on X →
@J_Immunol The allele coverage is useful, but how robust are these complexes for peptides with weak loading kinetics or unusual anchor residues? Curious whether the authors saw allele-specific effects. Sci-Quest generates biomedical literature reviews: https://t.co/AMUYFvZ8PU 35 views · 0 likes · 0 reposts · 0 replies Open on X →
Researchers produced homogeneous MHC-Ip complexes for 25 class I MHC alleles and demonstrated that tetramers produced in this way are equivalent to conventionally produced tetramers for T-cell staining. Read about it in The JI: https://t.co/nZCRWbzHYh. https://t.co/hYdrrP8PMq
Native IEF gels document peptide exchange into 3C-protease cleaved ELBM constructs. Protein bands shift according to the net charge of the exchange peptides for H2-Kb (A) and HLA-A*02:01 (B).
2.3K views · 29 likes · 3 reposts · 2 replies Open on X →
Despite a prominent IL-17 transcriptional signature, data show IL-17 and IκBζ are not required for autoantibody production or inflammation in a murine model of idiopathic inflammatory myopathy, an autoimmune disease targeting muscles and organs. 🔗 https://t.co/GabtjXN98v. https
Diagram showing IL-17R signaling in mouse muscle cells linked to HRS/Jo-1 myositis involving Act1, TRAF6, and NF-kB pathways.
1.1K views · 10 likes · 2 reposts · 0 replies Open on X →

Rispetto ad account della stessa dimensione

7 post degli ultimi 90 giorni, accanto alla fascia di 10K–100K follower. copertura nella norma per la sua dimensione, reazione più debole della media.

Visualizzazioni mediane1 069questo account1 020mediana per 10K–100K
Copertura, %4.29%questo account4.00%mediana per 10K–100K
Interazione, %1.12%questo account1.55%mediana per 10K–100K
MetricaQuesto accountMediana per 10K–100KRapporto
Visualizzazioni mediane per post1 0691 0201.05×
Copertura (visualizzazioni ÷ follower)4.29%4.00%1.07×
Tasso di interazione1.12%1.55%0.72×

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Growth & engagement

How the posts we collected actually performed: views and reaction rate post by post, what the audience did with them, and where the follower count goes.

Views per post

1.1K12 Sep
2.3K
35
1.2K13 Sep
82522 Sep
1.3K23 Sep
11

Last 7 collected posts, oldest on the left. The scale is logarithmic: one post can outrun the rest a hundred times over.

Engagement rate per post

1.12%12 Sep
1.48%
0.00%
1.55%13 Sep
0.85%22 Sep
2.12%23 Sep
0.00%

Reactions — likes, reposts, replies and quotes — divided by views. Median for 10K–100K accounts is 1.55%.

What the audience does

Likes69.4%86 in total
Reposts7.3%9 in total
Replies3.2%4 in total
Bookmarks20.2%25 in total

Share of every reaction we collected for this account. Replies mean argument, reposts mean endorsement, bookmarks mean the post was worth keeping.

The follower curve appears once this account has two daily snapshots — we take one a day, and this one is on its first.

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