Jonas Koeppel @JonasKoeppel · 03 Jun 2026

12/n For example, surviving deletions at this locus are depleted of deletions that intersect WDR3, an essential gene. Generally, Shred-seq lets us identify constrained loci by looking for places where the surviving deletion profile deviates from expected Cas3 distribution https://t.co/f2G7lbecww

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