🫀 Statins for primary prevention: 4 RCTs, 3 decades AFCAPS→JUPITER→HO

Gregg Fonarow MD @gcfmd · 02 Sep 2026

🫀 Statins for primary prevention: 4 RCTs, 3 decades AFCAPS→JUPITER→HOPE-3→STAREE 📉 24–44% ↓ major CV events Even at baseline LDL (108 mg/dL) No heterogeneity across subgroups in RRR  🟰 Safety ≈ placebo, few exceptions  ⚖️ Benefits ≫ risks 💊 cost $30/year https://t.co/cFVgoFRxRe

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