Afshine Emrani MD FACC @afshineemrani · 04 Sep 2026
5/12 Semaglutide is a potent GLP-1R agonist. Strong key for one lock.Tirzepatide is a dual GIP/GLP-1 agonist. At GLP-1R it is actually a biased agonist: good cAMP signaling, relatively weak β-arrestin pull, less internalization. Plus it hits GIP receptors in fat tissue and brain
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