Afshine Emrani MD FACC ✓

@afshineemrani · Los Angeles, CA · joined 13 Sep 2009

Cardiologist. Author. Jew. ✡️ Zionist. 🇮🇱 Love America 🇺🇸 Kaballah. Rumi. Japanese antiques. #BTC #FreeIran Insta: @afshineemrani https://t.co/tfPX6gIvwS

118 186Followers

203Following

111 625Posts total

72KViews on collected posts

Against accounts of the same size

20 posts from the last 90 days, next to the 100K–1M follower range. reaches fewer people than peers of the same size.

Median views680this account5 854median for 100K–1M

Reach, %0.58%this account2.44%median for 100K–1M

Engagement, %1.16%this account1.42%median for 100K–1M

Metric	This account	Median for 100K–1M	Ratio
Median views per post	680	5 854	0.12×
Reach (views ÷ followers)	0.58%	2.44%	0.24×
Engagement rate	1.16%	1.42%	0.81×

Others in this range → Compare with another account → How these benchmarks are built →

Growth & engagement

How the posts we collected actually performed: views and reaction rate post by post, what the audience did with them, and where the follower count goes.

Views per post

7394 Sep

708

679

681

620

515

492

490

609

539

457

146

2.2K

1.8K

Last 14 collected posts, oldest on the left. The scale is logarithmic: one post can outrun the rest a hundred times over.

Engagement rate per post

0.81%4 Sep

0.71%

0.74%

0.73%

0.81%

1.17%

1.22%

1.43%

1.15%

1.30%

0.22%

0.00%

7.16%

1.31%

Reactions — likes, reposts, replies and quotes — divided by views. Median for 100K–1M accounts is 1.42%.

What the audience does

Likes71.6%624 in total

Reposts6.8%59 in total

Replies8.3%72 in total

Quotes0.6%5 in total

Bookmarks12.7%111 in total

Share of every reaction we collected for this account. Replies mean argument, reposts mean endorsement, bookmarks mean the post was worth keeping.

The follower curve appears once this account has two daily snapshots — we take one a day, and this one is on its first.

Latest posts

When we got married, my wife and I went out to dinner every Saturday night. We called them Romantic Date Nights. Then came the kids. Dinner became playdates and birthday parties so loud you could feel your fillings vibrate. We called them Romantic Mommy-and-Me Parties. (I miss 1.8K views · 20 likes · 1 reposts · 3 replies 04 Sep 2026 Marco Rubio will be the next President. 2.2K views · 133 likes · 9 reposts · 15 replies 04 Sep 2026 @afshineemrani My sister is taking the wegovy pill and it has barely worked. She lost only 12 lbs in about 6 months. She really struggles with weight so I don’t blame her for giving in and taking the drug. The problem is she hates the emotional side effects: the flatness, lack of 146 views · 0 likes · 0 reposts · 0 replies 04 Sep 2026 https://t.co/RMH4MZqVtg 457 views · 1 likes · 0 reposts · 0 replies 04 Sep 2026 12/12 Save this.The drug is a key. The GLP-1 receptor is the lock. Your phenotype is which door is jammed. Dose, protein, muscle, sleep, and other medications decide whether the key even reaches the door.40 lb on two pens and 4 lb on the highest dose can both be honest biology.If 539 views · 7 likes · 0 reposts · 0 replies 04 Sep 2026 11/12 What “working” actually looks like, so you stop measuring yourself against the 40-lb outlier.• Food noise drops before the scale does. That is the receptor in the brain. • Portions shrink without a speech about discipline. That is satiation. • The gap between meals gets 609 views · 6 likes · 0 reposts · 1 replies 04 Sep 2026 10/12 Screenshot this protocol. Confirm the product, the day, the site rotation, and 12 full weeks at the dose that is supposed to work. Protein first. Target 1.2–1.6 g per kg of body weight per day. For a lot of adults that is 80–120 g or more. Eat it at the start of the meal. 490 views · 6 likes · 0 reposts · 1 replies 04 Sep 2026 9/12 Before you call yourself a non-responder, most “failures” are still one of these:• Still on a starter dose. 0.25 mg and 2.5 mg exist so your stomach survives week one. They are not the working dose. • Not 12 weeks at a therapeutic dose. For semaglutide that usually means 492 views · 5 likes · 0 reposts · 1 replies 04 Sep 2026 8/12 Layer phenotype on top of the receptor. This is the map that explains the 40-lb patient and the 4-lb patient on the same pen.Hungry gut — normal plate, starving again in 90 minutes. Stomach empties fast. The gut often under-makes its own GLP-1 and PYY. These people are 515 views · 5 likes · 0 reposts · 1 replies 04 Sep 2026 7/12 There is a second genetic story that is not the receptor itself.~10% of people carry PAM variants that create a kind of GLP-1 resistance: they run higher circulating GLP-1, but the hormone does less work. More key in the blood, weaker effect at the lock. That is not “you ate 620 views · 4 likes · 0 reposts · 1 replies 04 Sep 2026 6/12 Genetics change the lock.A missense variant in GLP1R (rs10305420, Pro7Leu, in the signal peptide) was linked in a ~15–28k person analysis to extra weight loss — roughly 0.8 kg more per copy of the effect allele. Likely by helping more receptor get trafficked to the cell 681 views · 4 likes · 0 reposts · 1 replies 04 Sep 2026 5/12 Semaglutide is a potent GLP-1R agonist. Strong key for one lock.Tirzepatide is a dual GIP/GLP-1 agonist. At GLP-1R it is actually a biased agonist: good cAMP signaling, relatively weak β-arrestin pull, less internalization. Plus it hits GIP receptors in fat tissue and brain 679 views · 4 likes · 0 reposts · 1 replies 04 Sep 2026 4/12 Agonists that favor cAMP and keep more receptor on the membrane tend to keep working longer. Agonists that yank the receptor inside faster can desensitize the cell.This is why two GLP-1 drugs are not interchangeable even if both say “GLP-1.”4/12 Now the part almost nobody 708 views · 4 likes · 0 reposts · 1 replies 04 Sep 2026 3/12 Your own GLP-1 is a short-lived meal hormone from gut L-cells. It lasts minutes. The drugs last a week because they were engineered not to be chewed up by DPP-4.Weight loss is mostly brain-driven reduced intake, not a faster metabolism. The drug reaches receptors around 739 views · 5 likes · 0 reposts · 1 replies 04 Sep 2026 2/12 GLP-1 drugs do not melt fat.They are keys. The lock is the GLP-1 receptor (GLP-1R) — a G-protein-coupled receptor on cells in:• brainstem and hypothalamus (appetite, “food noise,” reward) • vagus nerve (gut-to-brain fullness signal) • stomach and intestine (slow emptying) 785 views · 9 likes · 0 reposts · 1 replies 04 Sep 2026 I'm a cardiologist. Here's a big challenge: The same GLP-1 pen. One patient loses 40 lb after a few doses. Another barely moves on the highest dose. That is not willpower. It is often the receptor the drug has to bind. If the shot “isn’t working,” read this before you quit or 7K views · 29 likes · 2 reposts · 4 replies 04 Sep 2026 The Last Time, and Nobody Noticed One day your parents picked you up for the last time, and neither of you realized it. There was no ceremony. You were heavy, or restless, or simply old enough to walk, and the arms that had lifted you a thousand times set you down and never 2K views · 24 likes · 2 reposts · 3 replies 04 Sep 2026 @afshineemrani OH STFU...She committed a fireable offense... They literally called her CRAZY!!! https://t.co/Cqzam6EvGo 381 views · 8 likes · 0 reposts · 1 replies 04 Sep 2026 Dear @POTUS @realDonaldTrump Here’s your chance to slap FOX in the face by making the great @MariaBartiromo the White House Press Secretary. 2.1K views · 27 likes · 5 reposts · 1 replies 04 Sep 2026 Fox just fired Maria Bartiromo. She wanted to report China’s role in the 2020 election. Fox execs texted producers: kill it. She sent the order to the White House. They fired her. 12 years. Three number-one shows. Gone overnight. No goodbye. They never went through Hannity, ht 49.1K views · 323 likes · 40 reposts · 35 replies 04 Sep 2026

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