Afshine Emrani MD FACC @afshineemrani · 04 Sep 2026
6/12 Genetics change the lock.A missense variant in GLP1R (rs10305420, Pro7Leu, in the signal peptide) was linked in a ~15–28k person analysis to extra weight loss — roughly 0.8 kg more per copy of the effect allele. Likely by helping more receptor get trafficked to the cell
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