Prof. Akiko Iwasaki ✓
@VirusesImmunity · New Haven, CT · joined 16 May 2017
We study antiviral immunity and viral disease pathogenesis. #COVID19 #longCOVID #vaccines @HHMINEWS @YaleIBIO @YaleMed @YaleCII
211 118Followers
1 924Following
14 775Posts total
464.2KViews on collected posts
Latest posts
Looking for new posts…
Exciting opportunity at Yale 📢 We are seeking a Medical Director for the Yale New Haven Hospital Multi-Specialty Long COVID Care Center. Pls spread the word!
Interested candidates should contact @LisaSandersMD.
#LongCOVID #Medicine #InternalMedicine #PostAcuteInfectionSyndrome h
16.7K views · 202 likes
· 85 reposts · 8 replies
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@VirusesImmunity @alex_winnett @S_Tabachnikova @ismagilovlab Why don't you ask why many with #LongCovid can't get vaccinated without clinically deteriorating.
That would be useful.
369 views · 8 likes
· 1 reposts · 2 replies
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Implication: if we want vaccines that limit transmission, not just disease, we may need to seed TRM in the nose. Current intramuscular vaccines do this to some extent, but poorly. Prime & Spike strategies do this very well. As always, very grateful to all who contributed 🙏🏼 https
7.5K views · 193 likes
· 43 reposts · 9 replies
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But it's the Type II IFN (IFN-γ) that actually appears to matter for controlling viral replication. Earlier mucosal IFN-γ correlated with 10–100x lower viral load. COVID vaccination was associated with earlier Type II IFN responses. (4/) https://t.co/oRavIREfFD
1.8K views · 57 likes
· 11 reposts · 2 replies
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How does vaccination help beyond antibodies? Vaccinated individuals had higher tissue-resident memory T cell (TRM) signatures in the nasal mucosa and mounted Type II IFN responses earlier. This points to mucosal TRM as a key mechanism — and a target for next-gen vaccines. (5/) ht
3.8K views · 75 likes
· 12 reposts · 4 replies
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We found that Type I IFNs fired fast and synchronously across all three sites — even before the virus was detectable locally. Remarkable coordination. Typically, SARS-CoV-2 was detected first in the oral cavity/ oropharynx, then in the nasal cavity. (3/) https://t.co/Hf6odPgUdE
2.8K views · 67 likes
· 12 reposts · 2 replies
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New preprint by @alex_winnett @S_Tabachnikova et al.! We asked: which cellular immune signals control viral replication in the nose during the first days of SARS-CoV-2 infection — and how do they change with vaccination? With @ismagilovlab (1/)
https://t.co/HIpMpvahDc https://t.
49.1K views · 358 likes
· 149 reposts · 6 replies
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We collected 1,237 daily swabs from the nasal, oral, and oropharyngeal sites of people starting before naturally acquired COVID-19 infection. This temporally dense, multi-site mucosal sampling gave us a unique platform to probe the immune protective signature via RNAseq. (2/) htt
4.2K views · 73 likes
· 11 reposts · 1 replies
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@VirusesImmunity @keylas3 @PutrinoLab So you mean inducing spike protein production by genetic therapy caused auto immunity.
Who'd have thought hey.
Why are you still calling it "Long COVID"?
4.4K views · 409 likes
· 67 reposts · 15 replies
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Whether this autoantibody subgroup of Long COVID could benefit from FcRn inhibitors, B cell depletion therapies, etc., needs to be examined in future studies. So grateful to all co-authors & participants dedicated to better understanding the pathophysiology of Long COVID🙏🏼 https:
43.1K views · 465 likes
· 97 reposts · 13 replies
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Open-access link of our study is found here 👇🏼https://t.co/PT2EEI3iYj
13K views · 306 likes
· 74 reposts · 21 replies
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Finally, patients' IgG injection led to activation of neurons in recipient mice in brain regions associated with pain, fatigue, emotional distress, sensory overload, and arousal regulation - conducted by Marc Schneeberger Páne group https://t.co/NXvnDJV2XO
7.1K views · 238 likes
· 49 reposts · 7 replies
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This work builds on prior work by other groups, such as @DrDenDunnen Chen et al. DOI: 10.1016/j.xcrm.2026.102693, Mignolet et al. DOI: 10.1007/s00401-026-03019-0, and of course, the original demonstration in fibromyalgia Goebel et al. DOI: 10.1172/JCI144201
4.5K views · 164 likes
· 21 reposts · 2 replies
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When purified IgG from patients with LC was transferred into naive healthy mice, it was sufficient to induce heightened heat sensitivity. With help from Tamas Horvath group. IgG that caused heat pain in mice came from patients reporting chronic pain! https://t.co/SivE4mb8Qk
6.4K views · 247 likes
· 46 reposts · 2 replies
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The nociceptor neurons responsible for sensing heat in the skin were damaged shortly after the patients' IgG injection. We also see human IgG around the remaining nociceptor in the skin. Analysis by @bakermind https://t.co/SlIaFCHFZN
6.8K views · 217 likes
· 29 reposts · 4 replies
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Using tissue-based staining, a human proteome array, ELISA, IgG-pull down and mass spec, we identified a wide array of autoantibodies in those with LC. IgG targeting neurological antigens, such as NMDAR, were elevated in LC. Collab with CellTrend and @C_Scheibenbogen 🙏🏼 https://t
8.3K views · 250 likes
· 47 reposts · 2 replies
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With SeromYx, we found that autoantibodies to MED20 in LC have undergone class switching to IgG from IgM, bind to many FcgRs, and induce robust phagocytosis when in immune complexes compared to IgG from control participants https://t.co/2L7ni6OTLA
6K views · 183 likes
· 29 reposts · 1 replies
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Excited to share our study by @keylas3 et al. on pathological autoantibodies in people with Long COVID. We asked whether IgG in patients with Long COVID bind to human tissues/antigens and cause pathologies when transferred into mice. With @PutrinoLab
https://t.co/tcowCufWyf htt
235.1K views · 1.3K likes
· 473 reposts · 93 replies
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'STORM' is a short documentary about Scott Hugo. A story of Long COVID's impact on his life and family - a reminder of what is at stake in research on Long COVID.
His resilience humbles me.
Please watch and share 🙏🏼
https://t.co/tN7B5wcq2I
43.1K views · 465 likes
· 165 reposts · 13 replies
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To all aspiring young #WomenInSTEM:
Mentee: Should I avoid being pregnant while trying to secure a faculty position?
Me: Be pregnant & go on interviews. If they don’t welcome you with open arms and offer childcare options, they don’t deserve you. #KnowYourWorth
0 views · 9.3K likes
· 1.4K reposts · 493 replies
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Against accounts of the same size
8 posts from the last 90 days, next to the 100K–1M follower range. ordinary reach for its size, stronger reaction than most.
Median views4 030this account5 948median for 100K–1M
Reach, %1.91%this account1.60%median for 100K–1M
Engagement, %2.65%this account1.04%median for 100K–1M
| Metric | This account | Median for 100K–1M | Ratio |
|---|---|---|---|
| Median views per post | 4 030 | 5 948 | 0.68× |
| Reach (views ÷ followers) | 1.91% | 1.60% | 1.19× |
| Engagement rate | 2.65% | 1.04% | 2.55× |
Others in this range → Compare with another account → How these benchmarks are built →
Growth & engagement
How the posts we collected actually performed: views and reaction rate post by post, what the audience did with them, and where the follower count goes.
Views per post
6.4K28 May
4.5K
7.1K
13K
43.1K
4.4K29 May
4.2K12 Jul
49.1K
2.8K
3.8K
1.8K
7.5K
36913 Jul
16.7K8 Sep
Last 14 collected posts, oldest on the left. The scale is logarithmic: one post can outrun the rest a hundred times over.
Engagement rate per post
4.62%28 May
4.11%
4.15%
3.07%
1.33%
11.17%29 May
2.00%12 Jul
1.05%
2.91%
2.39%
3.91%
3.25%
2.98%13 Jul
1.77%8 Sep
Reactions — likes, reposts, replies and quotes — divided by views. Median for 100K–1M accounts is 1.04%.
What the audience does
Likes64.4%5 275 in total
Reposts17.4%1 421 in total
Replies2.5%207 in total
Bookmarks15.7%1 285 in total
Share of every reaction we collected for this account. Replies mean argument, reposts mean endorsement, bookmarks mean the post was worth keeping.
The follower curve appears once this account has two daily snapshots — we take one a day, and this one is on its first.
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