David R. Liu ✓

@davidrliu · Massachusetts, USA · joined 28 Nov 2008

Professor at Harvard and the Broad Institute. Our lab integrates chemistry & evolution to illuminate biology & enable new therapeutics. IG/Threads: @davidrliu1

80 125Followers

69Following

3 581Posts total

415.5KViews on collected posts

Against accounts of the same size

6 posts from the last 90 days, next to the 10K–100K follower range. shown widely, but few of those viewers react.

Median views60 656this account3 383median for 10K–100K

Reach, %75.70%this account10.96%median for 10K–100K

Engagement, %0.82%this account1.40%median for 10K–100K

Metric	This account	Median for 10K–100K	Ratio
Median views per post	60 656	3 383	17.9×
Reach (views ÷ followers)	75.70%	10.96%	6.91×
Engagement rate	0.82%	1.40%	0.58×

Others in this range → Compare with another account → How these benchmarks are built →

Growth & engagement

How the posts we collected actually performed: views and reaction rate post by post, what the audience did with them, and where the follower count goes.

Views per post

22.8K22 Jul

115.3K

121.2K31 Jul

47.8K1 Aug

35K3 Aug

73.5K12 Aug

Last 6 collected posts, oldest on the left. The scale is logarithmic: one post can outrun the rest a hundred times over.

Engagement rate per post

1.40%22 Jul

0.88%

0.64%31 Jul

0.71%1 Aug

1.28%3 Aug

0.76%12 Aug

Reactions — likes, reposts, replies and quotes — divided by views. Median for 10K–100K accounts is 1.40%.

What the audience does

Likes62.4%2 670 in total

Reposts15.8%678 in total

Replies1.1%45 in total

Quotes1.4%62 in total

Bookmarks19.3%825 in total

Share of every reaction we collected for this account. Replies mean argument, reposts mean endorsement, bookmarks mean the post was worth keeping.

The follower curve appears once this account has two daily snapshots — we take one a day, and this one is on its first.

Latest posts

Today in @NatureBiotech we report OptiPrime, a mechanism-based machine learning model for predicting prime editing (PE) efficiencies and suggesting pegRNAs to achieve a user-specified edit. OptiPrime incorporates biochemical knowledge about PE into its mathematical structure, 73.5K views · 429 likes · 112 reposts · 5 replies 12 Aug 2026 Today in @NatureBiotech we report the use of phage-assisted evolution (PACE) to reprogram botulinum neurotoxin (BoNT) proteases to trigger cancer cell death. We evolved proteases to cleave procaspase-1 or gasdermin D, inducing cell death and slowing tumor growth in a highly https 35K views · 358 likes · 81 reposts · 7 replies 03 Aug 2026 Amazing new work by @JShendure and coworkers uses a clever application of prime editing called DNA Typewriter to trace the lineage of a developing mouse from zygote to middle of day 14 at a single-cell level. See Jay’s beautiful tweetorial: 47.8K views · 292 likes · 47 reposts · 0 replies 01 Aug 2026 Thrilled to post thread re: new single-cell lineage of mouse embryo reconstructed w/ DNA Typewriter. One animal, zygote to late organogenesis (E13.5). Tree has 1,340,794 transcriptionally profiled, annotated tips (cells), 1,142,588 dated internal nodes, rooted at zygote 1/n http 121.2K views · 543 likes · 185 reposts · 15 replies 31 Jul 2026 Today in @Nature we report how AI-guided redesign enhances protein evolution. Integrating ProteinMPNN sequence design with autonomous laboratory evolution, we establish a workflow to engineer enzymes with improved properties over those evolved from natural proteins. Redesigned h 115.3K views · 807 likes · 187 reposts · 9 replies 22 Jul 2026 Experts in gene editing, n=1 medicine development, in vivo delivery, rare diseases, and cell & animal models of genetic disorders have founded the Center for Therapeutic Genetics (CTG), a non-profit effort involving @broadinstitute @BostonChildrens @jacksonlab, as well as oth 22.8K views · 241 likes · 66 reposts · 9 replies 22 Jul 2026