Michael Morelli ✓
@morellifit · Florida, USA · joined 23 May 2011
Founder of FitScript, Northblu, PeptideU, PawGen, and others. F*ck aging. Peptides, protocols, and the future of human (& canine) longevity. Dog Longevity👇🏼
223 658Followers
505Following
51 551Posts total
1.7MViews on collected posts
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Our environment is broken.
When animals with no access to fast food or sedentary jobs gain weight at the same rate we do, the common factor is what we all share, i.e. environment.
Filter your water, ditch plastic food containers, and get your pets off the same toxic exposures.
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Scientists analyzed 60 years of weight records from 20,000+ animals.
Cats, dogs, mice, rats, monkeys and chimps, and EVERY SINGLE ONE got fatter.
The odds of this being a coincidence are 1 in 8 million.
This is what it means for your health: (1/18) https://t.co/JfeUro1Jls
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10 days in and all I know is…
FLGR-242 is making my training fun again.
Let's see if the data is congruent to how I am feeling / what I am seeing.
20 days until the second DEXA. https://t.co/mN54Ilese3
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@morellifit Once I see some safety studies, I’ll consider looking into it
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P.S. None of this is medical advice or a recommendation.
FLGR-242 is experimental and does not have an established human safety or dosing profile.
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Whether that translates into meaningful results in humans is what I want to find out.
I’ll share what happens as I get more data from my own use.
If anyone else has used FLGR-242, I’m curious what you tracked and what changed.
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Still, I understand why it's getting attention.
Myostatin is a well-established regulator of muscle mass, and follistatin has produced measurable effects in mice and small human gene-therapy studies.
FLGR-242 is an attempt to make that biology last longer in circulation.
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There's currently no published human data showing its actual half-life, effective dose, long-term safety or how much it affects muscle growth.
For FLGR-242 specifically, those numbers just don’t exist yet.
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I'm currently on 2.5 mg once per week and will increase after 4 weeks.
Tracking everything with https://t.co/BgpHBhr9q0 app, which might be dopest app I’ve ever seen.
I use it to log everything. https://t.co/mbrYt2jcMT
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FLGR-242 is built around that same biology, but the molecule itself is different.
It’s described as a modified follistatin construct attached to an albumin-binding sequence.
The albumin-binding part is designed to keep it circulating for longer. https://t.co/7GFVdBnJtD
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Two of those patients improved by more than 100 meters.
There were signs of muscle hypertrophy in treated areas as well, although strength improvements were inconsistent.
This showed follistatin could be pushed far enough to produce measurable effects in humans.
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Follistatin was later tested in humans through gene therapy.
Six men with Becker muscular dystrophy received AAV-FS344.
Four of them improved their 6-minute walking distance, and the group averaged an 11.5% improvement at 6 months.
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One study tested Follistatin-288 in mice.
Mice given recombinant Follistatin-288 every day for 13 weeks gained lean mass while accumulating less fat.
At the highest dose, gastrocnemius muscle weight was 41% higher than controls.
EDL muscle was 29% higher. https://t.co/QJL5jImX
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Follistatin is one of the proteins that can interfere with this pathway.
It binds myostatin and prevents it from activating its receptor.
Researchers have been studying that interaction for years as a possible way to preserve or rebuild muscle. https://t.co/isPQFrD0Gq
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By age 4.5, he could hold two 3 kg dumbbells horizontally with his arms extended.
He had unusually high muscle mass and strength from early childhood.
This gave researchers strong evidence that myostatin regulates muscle growth in humans.
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We’ve seen something similar in humans as well.
In 2004, doctors reported a child with a rare mutation that severely reduced myostatin production.
His quadriceps were more than twice the cross-sectional size of matched controls. https://t.co/oxqXkUcigt
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Myostatin is basically your genetic muscle ceiling.
When researchers knocked out the myostatin gene in mice, their skeletal muscle mass roughly doubled.
Even cattle with myostatin mutations can carry 20-25% more muscle. https://t.co/vSikKBvz12
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FLGR-242 is based on follistatin, a protein produced by your body.
One of follistatin’s targets is myostatin.
Myostatin puts a limit on how much skeletal muscle you build, which is why researchers have been trying to block this pathway for decades.
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This peptide could make steroids obsolete.
It's called FLGR-242 and I've recently added it to my protocol.
It blocks myostatin, the protein that caps muscle growth. The dog below was born with no working myostatin, and that's the result.
Here's the breakdown: (1/15) https://t.
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@morellifit Show the video of your dog jumping on the patio. You just showed an old dog getting an injection, dork.
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Today we launched PETIDES because every dog deserves more energy, better mobility, and more quality time with their family.
This is the exact protocol we're using and the one that gave my boy his spark back.
See how it works here: https://t.co/yWxsSAANyV
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I revived my 14-year-old dog with peptides.
6 months ago, he was slowing down fast. He was limping, achy, getting up slowly, and couldn't jump on the couch.
We honestly didn't know if we had 6 months left with him.
Today, our boy is running, jumping on the patio, going on long
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0:32
Against accounts of the same size
24 posts from the last 90 days, next to the 100K–1M follower range. shown widely, but few of those viewers react.
Median views16 334this account6 070median for 100K–1M
Reach, %7.30%this account1.60%median for 100K–1M
Engagement, %0.22%this account0.97%median for 100K–1M
| Metric | This account | Median for 100K–1M | Ratio |
|---|---|---|---|
| Median views per post | 16 334 | 6 070 | 2.69× |
| Reach (views ÷ followers) | 7.30% | 1.60% | 4.56× |
| Engagement rate | 0.22% | 0.97% | 0.22× |
Others in this range → Compare with another account → How these benchmarks are built →
Growth & engagement
How the posts we collected actually performed: views and reaction rate post by post, what the audience did with them, and where the follower count goes.
Views per post
16.2K12 Sep
16K
16.5K
15.5K
14.3K
13.8K
14.3K
13.5K
10.9K
45.5K16 Sep
28.1K
6.7K
10.5K17 Sep
4K
Last 14 collected posts, oldest on the left. The scale is logarithmic: one post can outrun the rest a hundred times over.
Engagement rate per post
0.22%12 Sep
0.17%
0.15%
0.41%
0.22%
0.17%
0.16%
0.25%
0.67%
0.25%16 Sep
0.87%
0.09%
0.40%17 Sep
0.17%
Reactions — likes, reposts, replies and quotes — divided by views. Median for 100K–1M accounts is 0.97%.
What the audience does
Likes49.4%5 269 in total
Reposts3.8%407 in total
Replies4.2%443 in total
Quotes1.1%118 in total
Bookmarks41.5%4 430 in total
Share of every reaction we collected for this account. Replies mean argument, reposts mean endorsement, bookmarks mean the post was worth keeping.
The follower curve appears once this account has two daily snapshots — we take one a day, and this one is on its first.
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