Patrick Hsu ✓
@pdhsu · joined 17 Mar 2009
@ArcInstitute co-founder, @Stanford professor, @ThriveCapital investor | biology and ML research | 🇨🇦 prev @harvard @broadinstitute, Fast Grants
86 608Followers
3 265Following
4 696Posts total
4.9MViews on collected posts
Latest posts
Looking for new posts…
multi-target RNAi has so much potential. PCSK9 drugs dramatically lower LDL but have modest effects on triglycerides. substantially lowering both with one drug is exciting.
heart disease is the leading cause of death in the US and globally. cardiovascular patients are entering
9.4K views · 51 likes
· 6 reposts · 1 replies
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@natfriedman is truly one of a kind. an inspiration!
16.5K views · 81 likes
· 1 reposts · 0 replies
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something most folks who use muse won't ever know or appreciate was the degree to which this was @natfriedman's baby.
it has been one of the great honors of my career watching nat cook. he assembled and ran the team, and so many of the little details that people love came from
354.8K views · 3.5K likes
· 93 reposts · 111 replies
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$ARWR out with dual-targeting PCSK9/ApoC3 RNAi dimer for mixed hyperlipidemia.
Mean max following single admin:
ApoC3 -88% --> -73% trig
PCSK9 -72% (gene not just expressed in liver) --> -54% LDLc
ApoB -50%
Not much, if any competition between RNAi triggers.
Now waiting for
17.5K views · 38 likes
· 2 reposts · 2 replies
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My best health discovery for the quarter - drinking 20-25g of unflavored highly branched cyclic dextrin before my workout + sugar free electrolytes
I worked out fasted for most of my life and as I’ve gotten older, I’d get absolutely toasted with slow recovery and
31.5K views · 232 likes
· 2 reposts · 18 replies
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Today in @ScienceMagazine, we report a new DNA editing technology to seamlessly write massive changes into the right place in the human genome.
The reason gene editing hasn't transformed human health is that current gene editing technologies like CRISPR are very limited.
The ht
744.4K views · 3K likes
· 670 reposts · 80 replies
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@pdhsu @Nature I would say that the Broad Institute could not be trusted with this technology and there should be an immediate worldwide moratorium on it.
How's that?
1.8K views · 111 likes
· 27 reposts · 5 replies
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Thanks also to @connorjtou and @BKleinstiver for this great News and Views in @Nature on our two studies!
https://t.co/0VM0A6qItv
17.1K views · 135 likes
· 20 reposts · 6 replies
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Moving forward, I'm particularly interested in programming biology across multiple lengthscales, including tissues and physiology.
We're hiring across ML and experimental positions for folks interested in combining biology and AI. Come join us at @arcinstitute!
Here are the ht
19.1K views · 123 likes
· 9 reposts · 6 replies
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This was a 2+ year detective story uniquely enabled by the @arcinstitute model, blending Arc's technical staff, PhD students from our partner universities, and hybrid computational & experimental science.
Matt, Nick, and the team have moved mountains to bring you this https://t.
15.9K views · 106 likes
· 3 reposts · 1 replies
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Together, I think these studies open up entirely new directions and we are excited to explore them through many collaborations
The bridge discovery was co-led by the amazing duo of @mgdurrant and @ntperry13 with important contributions from @SKonermann, @jjwp1011, @Adi_R_Jangid,
16.1K views · 104 likes
· 6 reposts · 6 replies
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How does this enable large-scale genome design beyond editing individual bases or genes?
The experimental ability to universally rearrange/recombine DNA must be paired with the computational ability to design sequences at genome-scale
That's Evo, our AI foundation model with ht
16.8K views · 87 likes
· 5 reposts · 2 replies
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GIF
Inspired by Cre engineering, we show that reprogrammed bridge RNAs can direct insertion, excision, or inversion of DNA
This is a universal mechanism that makes the desired DNA rearrangement end-to-end in a single step https://t.co/A1e8m7VIT6
20.2K views · 97 likes
· 9 reposts · 1 replies
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Cre-Lox recombination has been a foundational tool for molecular biology and mouse genetics since its discovery in 1981. However, it is not programmable.
Scientists have spent decades trying to engineer and reprogram Cre to recognize DNA sites other than the LoxP sequence https:
18.7K views · 87 likes
· 4 reposts · 1 replies
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Unlike Cre, bridge recombination is fully programmable simply by changing the target binding loop (left) or donor binding loop (right)
These two loops can be modularly and separably reprogrammed https://t.co/fsUGIUQwCA
17.5K views · 92 likes
· 3 reposts · 2 replies
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CRISPR creates DNA nicks/breaks and requires complex DNA repair pathways in the cell to make a genome edit (like an insertion or deletion) beyond a cut
Bridge recombination works in vitro, without relying on cellular DNA repair mechanisms. This could lead to safer genome edits h
21K views · 149 likes
· 18 reposts · 3 replies
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In new collaborative work with @hnisimasu, we reveal the IS110 bridge mechanism in 3 distinct stages
The bispecific bridge RNA recruits two dimers of the IS110 recombinase, forming an elegant tetramer to exchange and religate 4 distinct DNA strands in a single step! https://t.co
30.1K views · 147 likes
· 18 reposts · 4 replies
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0:41
What if we could universally recombine, insert, delete, or invert any two pieces of DNA?
In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design ht
1.9M views · 5K likes
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1:32
See our previous thread on preprint here: https://t.co/z82IcKfGY7
Bridge RNA recombinases encode a mechanistically new class of guide RNAs
They are bispecific, unlike the CRISPR (2012) or RNA interference (1998) guide RNAs that specify only 1 target for a simple scissors cut ht
53.5K views · 254 likes
· 28 reposts · 3 replies
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Is DNA all you need?
In new work, we report Evo, a genomic foundation model that learns across the fundamental languages of biology: DNA, RNA, and proteins. Evo is capable of both prediction tasks and generative design, from molecular to whole genome scale. https://t.co/BPo9ggH
790.1K views · 2K likes
· 432 reposts · 39 replies
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GIF
Just shared at @KeystoneSymp a new @ArcInstitute discovery of the bridge RNA recombinase mechanism: a new class of natural RNA-guided systems that retains the key property of programmability from RNAi and CRISPR while enabling large-scale genome design beyond RNA and DNA cuts htt
779.3K views · 1.3K likes
· 320 reposts · 23 replies
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Against accounts of the same size
6 posts from the last 90 days, next to the 10K–100K follower range. shown widely, but few of those viewers react.
Median views20 520this account964median for 10K–100K
Reach, %23.69%this account3.55%median for 10K–100K
Engagement, %0.56%this account1.59%median for 10K–100K
| Metric | This account | Median for 10K–100K | Ratio |
|---|---|---|---|
| Median views per post | 20 520 | 964 | 21.3× |
| Reach (views ÷ followers) | 23.69% | 3.55% | 6.67× |
| Engagement rate | 0.56% | 1.59% | 0.35× |
Others in this range → Compare with another account → How these benchmarks are built →
Growth & engagement
How the posts we collected actually performed: views and reaction rate post by post, what the audience did with them, and where the follower count goes.
Views per post
20.2K26 Jun
16.8K
16.1K
15.9K
19.1K
17.1K
1.8K8 Jul
744.4K25 Sep
31.5K12 Sep
17.5K15 Sep
23.6K
354.8K
16.5K16 Sep
9.4K
Last 14 collected posts, oldest on the left. The scale is logarithmic: one post can outrun the rest a hundred times over.
Engagement rate per post
0.54%26 Jun
0.56%
0.73%
0.70%
0.72%
0.96%
7.85%8 Jul
0.51%25 Sep
0.80%12 Sep
0.25%15 Sep
0.42%
1.05%
0.50%16 Sep
0.62%
Reactions — likes, reposts, replies and quotes — divided by views. Median for 10K–100K accounts is 1.59%.
What the audience does
Likes61.9%16 830 in total
Reposts10.4%2 832 in total
Replies1.9%505 in total
Quotes2.0%537 in total
Bookmarks23.9%6 505 in total
Share of every reaction we collected for this account. Replies mean argument, reposts mean endorsement, bookmarks mean the post was worth keeping.
The follower curve appears once this account has two daily snapshots — we take one a day, and this one is on its first.
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